SPP 1172: The significance of neuroglia for the formation, function and plasticity of synapses (2004 – 2010)
Spokesperson:
Professor Dr. Joachim W. Deitmer
Technische Universität Kaiserslautern
Fachbereich Biologie
Fachgebiet Zoologie/Neurobiologie
Postfach 3049
67653 Kaiserslautern
Phone: +49 631 2052877
E-Mail: deitmer@biologie.uni-kl.de
Deputy: Professor Dr. Christian Steinhäuser
The Priority Programme aims to study the influence of neuroglia in a multidisciplinary approach, from molecular to systemic, on the brains prime functional structure for information processing, the synapse, under physiological conditions and during pathological changes.
- The programme is focussed on the following topics:
- neuron-glia interactions at neuronal synapses
- molecular relationships between synaptic elements, extracellular matrix molecules and glial cell processes
- role of glia for the formation, stabilisation and removal of synapses
- modulation of synaptic transmission by glia
- metabolic nuturing of synapses by glia
- significance of glial precursor cells (stem cells) for the formation and function of synapses
Meetings of the SPP 1172:
- 1st Meeting of the DFG-Priortity Programme 1172 “The role of neuroglia for the formation, function and plasticity of synapses”, Kaiserslautern (October 14 – 16, 2004)
- 2nd Meeting of the DFG-Priortity Programme 1172 “The role of neuroglia for the formation, function and plasticity of synapses”, Kaiserslautern (September 22 – 24, 2005)
- 3rd Meeting of the DFG-Priortity Programme 1172 “The role of neuroglia for the formation, function and plasticity of synapses”, Bonn (September 28 – 30, 2006)
- 4th Meeting of the DFG-Priortity Programme 1172 “The role of neuroglia for the formation, function and plasticity of synapses”, Bad Dürkheim/Pfalz (October 14 – 16, 2007)
- 5th Meeting of the DFG-Priortity Programme 1172 “The role of neuroglia for the formation, function and plasticity of synapses”, Berlin (September 18 – 20, 2008)
- 6th Meeting of the DFG-Priortity Programme 1172 “The role of neuroglia for the formation, function and plasticity of synapses”, Frankfurt/M. (October 2 – 3, 2009)
- Final Meeting of the DFG-Priortity Programme 1172 “The role of neuroglia for the formation, function and plasticity of synapses”, Kaiserslautern (August 26 – 29, 2010)
Grant applications and reports of the SPP 1172:
Projects of the SPP 1172:
- Analysis of single signalling molecules at the synaptic astroglia-neuron interface (project leader Kirchhoff, Frank)
- Astrocyte-to-neuron communication: functional relevance for synaptic transmission in the respiratory network? (project leader Hülsmann, Swen)
- Communication between cortical neurons and astrocytes by extracellular ATP and glutamate (project leader Illes, Peter)
- Die Rolle astroglialer Subtypen bei der Synapsenbildung adult (re)generierter Neurone (project leader Berninger, Benedikt)
- Glia-mediated control of extracellular GABA/glutamate balance in the developing cortex (project leader Kirischuk, Sergei)
- Glial responses at neuronal synapses and their purinergic modulation (project leader Deitmer, Joachim W.)
- Influence of the constitutive, conditional and inducible astroglia-derived tenascin-C ablation on synaptic function (project leader Schachner, Melitta)
- Investigating the function of astrocytes during neurotrophin-induced synaptogenesis and synaptic plasticity (project leader Dieterich, Daniela C.)
- Investigations on the ephrinA/EphA signalling system at the neuroglial interface – focus on synaptic morphology, plasticity and glutamate signalling (project leader Klein, Rüdiger)
- Coordination project (project leader Deitmer, Joachim W.)
- Modulation of signal transmission in the hippocampus by GluR-type astroglial cells (project leader Seifert, Gerald)
- Modulation of synaptic transmission by a novel activity-dependent regulatory mechanism of astrocytic gap junction coupling (project leader Hülsmann, Swen)
- Neue transgene Mausmodelle zur Untersuchungder Rolle von Astrozyten bei der Synaptogenese in vivo (project leader Pfrieger, Frank W.)
- Neuron-glia interaction at a giant mammalian synapse, the Calyx of Held (project leader Kettenmann, Helmut)
- Regulation of Glycine Neurotransmission by the Glial Glycine Transporter 1. (project leader Eulenburg, Volker)
- Regulation of synapse formation, plasticity and function by astroglial-derived extracellular matrix – tenascin-C and interacting proteoglycan ligands (project leader Faissner, Andreas)
- Role of Müller Glial Cells in Synaptic Development and Functioning of the Mammalian Retina (project leader Reichenbach, Andreas)
- Role of the Perisynaptic Extracellular Matrix in Synaptic Plasticity (project leader Gundelfinger, Eckart D.)
- Synaptically-induced sodium transients in glial cells (project leader Rose, Christine R.)
- Targeting astroglial metabolism in vivo: Consequences for astrocytes, neurons and synapses (project leader Hirrlinger, Ph.D., Johannes)
- The role of cells expressing the proteoglycan NG2 in glial-neuronal signalling and synapse formation (project leader Trotter, Ph.D., Jacqueline)
- Translation control of glial key players in neuron-glia interactions (project leader Theis, Martin)