SFB 507: The role of non-neuronal cells in neurological diseases (1995 – 2007)

Projects of the SFB 507: 

• A1 – Cortical spreading ischemia (project leader Dreier, Jens P.;  Einhäupl, Karl M.)
• A2 – The impact of astrocytes on brain endothelial cells in hypoxia (project leader Blasig, Ingolf )
• A3 – Glia activation – a key mechanism in the damage cascade of bacterial meningitis (project leader Weber, Jörg Reinhold )
• A4 – Studies on the cellular and molecular regulatory mechanisms of the endothelial system in the brain (project leader Paul, Martin )
• A05 – Mechanisms for recruiting myloid cells in the brain  (project leaders Dirnagl, Ulrich;  Priller, Josef )
• A06 – The role of endothelial NO synthase in cerebral vessel reactivity: modulating the enzyme activity by HMG-CoA reductase inhibition and influencing the development of the stroke volume during cerebral ischemia  (project leader Lindauer, Ute )
• A7 – The role of microglia in iron metabolism in the brain – damage of iron binding proteins during hypoxic and radical stress  (project leader Grune, Tilman )
• A09 – Angiogenesis during mild cerebral ischemia (project leader Endres, Matthias )
• B1 – Physiological properties of glia tumors (project leader Kettenmann, Helmut )
• B3 – Alteration of cell-cell interaction of glial tumor cells in vitro and in vivo after retroviral and liposomal cytokin gene transfer (project leader Reszka, Regina )
• B4 – Functional properties and manipulated differentiation of retinoblastoma cells (project leader Grantyn, Rosemarie )
• B06 – Cell impairment of the blood-brain barrier. A key mechanism in the damage cascade of bacterial meningitis  (project leaders Braun, Johannes Sebastian; Weber, Jörg Reinhold )
• B8 – Pain inhibition by migration of opioid containing immune cells into inflamed tissue (project leaders Stein, Christoph;  Welte, Martin )
• B9 – Thrombin as stimulus und modulator of microglia activation (project leader Hanisch, Uwe-Karsten )
• B10 – Molecular characterization of glioma (project leaders von Deimling, Andreas;  Wiestler, Otmar Dieter )
• B11 – The role of the network on non-neuronal cells in axonal spreading (project leaders Müller-Röver, Sven ;  Nitsch, Robert )
• B12 – The role of oligodendroglial chemokine receptors in myelination and demyelination – functional in vitro-in vivo correlations (project leaders Brück, Wolfgang; Stangel, Martin )
• B14 – Mechanisms of immune cell mediated impairment in chronical inflammation of the central nervous system  (project leaders Aktas, Orhan   Zipp, Frauke )
• B15 – Interactions among inflammatory processes and the peripheral nrevous system: studies on infection risk and prevention in CNS-mediated systemic immune depresseion in the rat model (project leaders Volk, Hans-Dieter;  Woiciechowsky, Christian )
• B16 – The role of microglia in post-lesion changes in layers of anterograde axonal degeneration (project leader Bechmann, Ingo )
• B18 – The proteasom in microglia and astrocytes and its role in infectuous and inflammatory progesses in the CNS (project leaders Dahlmann, Burkhardt ;  Kloetzel, Peter Michael )
• C1 – The role of glial cells in transneuronal changes after entorhinal lesion (project leader Nitsch, Robert )
• C2 – Expression and regulation of apolipoprotein E (APOE) in glia cells after experimental and neuropathological gegeneration (M. Alzheimer) (project leader Ohm, Thomas Georg )
• C03 – Functions of glia cells during epileptogenetic processes (project leaders Heinemann, Uwe ;  Kann, Oliver )
• C4 – Changes in the intracellular calcium concentration, fatty acid, and reactive oxygen species in pathologically altered and normal astrocytes and neurons (project leader Müller, Ph.D., Wolfgang )
• C5 – Studies on the communication between neuronal and immune cells using acute and chronical intracerebral-ventricular application of pro- und anti-inflammatory cytokines in animals (project leaders Volk, Hans-Dieter;  Woiciechowsky, Christian 
• C6 – Mikrogliaaktivierung durch geschädigte Neurone: Signalwege oxidativ modifizierter Lipide (project leader Ullrich, Oliver )
• C07 – In situ studies on the physiological mechanisms of microglia activation under pathophysiological conditions  (project leaders Eder, Claudia;  Schilling, Tom )
• C8 – Physiological properties of glia tumors (project leader Kettenmann, Helmut )
• C9 – Molecular invasion mechanisms of glioma cells (project leader von Deimling, Andreas )
• C10 – Communication of microglia cells with astrocytes and neurons (project leader Kettenmann, Helmut )
• C12 – The role of blood-brain barrier impairment for cerebral cortex dysfunction (project leader Heinemann, Uwe )
• Z – Central administraton project (project leader Einhäupl, Karl M. )
• Z2 – Two-photon laser scanning microscope (DPLSM) (project leader Einhäupl, Karl M. )